1). later endosomes, that was similar to the phenotype from the mutations in IBMPFD. Overexpression of Ankrd13 protein also stabilized ubiquitinated Cav-1 oligomers over the restricting membrane of enlarged endosomes. The connections with Ankrd13 was abrogated in IMBPFD-associated VCP mutants. Collectively, our outcomes claim that Ankrd13 protein cooperate with VCP to modify the lysosomal trafficking … Continue reading 1)